An infographic is "a visual representation of information in the form of a chart, graph, or other image accompanied by minimal text, intended to give and easily understood overview, often of a complex subject."
An excellent example from the CDC: Racial and Ethnic Disparities in Heart Disease
Think about layout and flow - how will you draw the viewer's eye through the beginning, middle and end of your "story"? Don't forget that "white space" is an important part of any design.
Think about color - choose a color palette to use consistently throughout your design. A frequent recommendation is to choose 3 primary colors, and then add lighter and darker shades of one of those colors. The Do's and Don'ts of Infographic Design suggests some tools that can be helpful for picking colors.
Think about typography - yes you can use more than one type font, but use different fonts consistently. How to Select the Best Typography for Your Infographic recommends using one font for "body text", one for section headings and captions, and one for large titles or captions.
What not to do:
It's important to choose the best kind of chart to display your data. Think about what the question is that you want your data to answer.
Here are some guidelines to match your data to types of charts: